Enables identical protein binding activity and protein-cysteine S-palmitoyltransferase activity. Involved in lipoprotein transport; protein palmitoylation; and regulation of programmed cell death. Located in Golgi membrane and Golgi-associated vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZDHHC17. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZDHHC17 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZDHHC17, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:76,558,693–76,560,264 | 204.3 kb | Distal (>10kb) Multiome | 1006 | |
| chr12:76,762,457–76,763,079 | 1.0 kb | Proximal (<10kb) | 180 | |
| chr12:76,763,225–76,765,030 | 58 bp | At TSS Multiome | 982 | |
| chr12:76,780,975–76,782,664 | 17.9 kb | Distal (>10kb) Multiome | 241 | |
| chr12:76,872,409–76,872,961 | 108.5 kb | Distal (>10kb) Multiome | 106 | |
| chr12:76,878,056–76,880,114 | 114.9 kb | Distal (>10kb) Multiome | 765 |
Genomic view of the ZDHHC17 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.