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DE-3.28

Submodule 14 genes

Mitochondrial calcium uptake and cell cycle regulation

This module contains 14 genes including MCU, THADA, RAP1GDS1, TLK1, and CDC42BPA, with enrichment in mitochondrial calcium uptake and cell cycle processes. Knockdown of SOX17, FOXA2, and GATA4 activates this module. Knockdown of EOMESODERMIN represses this module.

Key terms: negative regulation of endoplasmic reticulum calcium ion concentration positive regulation of mitochondrial calcium ion concentration intracellular calcium ion homeostasis calcium ion homeostasis Notable genes: MCU THADA RAP1GDS1 TLK1 CDC42BPA PDSS2 GALNT7 USP32

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (14)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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