The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.[provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for PDSS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDSS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDSS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:107,114,151–107,117,016 | 345.0 kb | Distal (>10kb) Multiome HiCAR | 998 | |
| chr6:107,458,801–107,460,297 | 78 bp | At TSS Multiome | 965 | |
| chr6:107,488,810–107,490,838 | 30.6 kb | Distal (>10kb) Multiome | 600 | |
| chr6:107,634,247–107,635,413 | 175.4 kb | Distal (>10kb) Multiome | 133 | |
| chr6:107,675,165–107,675,837 | 215.9 kb | Distal (>10kb) Multiome | 556 |
Genomic view of the PDSS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.