This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. This enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. Unlike other family members, this enzyme shows exclusive specificity for partially GalNAc-glycosylated acceptor substrates and shows no activity with non-glycosylated peptides. This protein may function as a follow-up enzyme in the initiation step of O-glycosylation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GALNT7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GALNT7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GALNT7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:173,073,972–173,074,966 | 94.3 kb | Distal (>10kb) Multiome | 454 | |
| chr4:173,167,923–173,170,542 | 1.1 kb | Proximal (<10kb) Multiome | 816 | |
| chr4:173,174,529–173,174,745 | 5.7 kb | Proximal (<10kb) | 125 | |
| chr4:173,333,360–173,335,855 | 166.7 kb | Distal (>10kb) Multiome | 1085 | |
| chr4:173,369,270–173,372,372 | 202.1 kb | Distal (>10kb) Multiome | 989 | |
| chr4:173,448,962–173,449,725 | 280.5 kb | Distal (>10kb) Multiome | 186 |
Genomic view of the GALNT7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.