This gene is the target of 2p21 choromosomal aberrations in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs) in this gene may be associated with type 2 diabetes and polycystic ovary syndrome. The encoded protein is likely involved in the death receptor pathway and apoptosis. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for THADA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = THADA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of THADA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:42,809,783–42,811,471 | 785.8 kb | Distal (>10kb) Multiome HiCAR | 1125 | |
| chr2:43,360,095–43,360,662 | 235.8 kb | Distal (>10kb) Multiome | 129 | |
| chr2:43,595,554–43,596,646 | 37 bp | At TSS Multiome | 954 | |
| chr2:43,636,715–43,638,161 | 41.2 kb | Distal (>10kb) Multiome | 536 | |
| chr2:43,724,902–43,725,564 | 129.2 kb | Distal (>10kb) Multiome | 329 | |
| chr2:43,773,887–43,774,528 | 178.0 kb | Distal (>10kb) Multiome | 682 |
Genomic view of the THADA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.