The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]).[supplied by OMIM, Feb 2010]
Transcription factors with Perturb-seq knockdown data for RAP1GDS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAP1GDS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAP1GDS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:98,142,736–98,143,939 | 118.0 kb | Distal (>10kb) Multiome | 658 | |
| chr4:98,251,092–98,251,438 | 9.9 kb | Proximal (<10kb) | 12 | |
| chr4:98,260,090–98,262,366 | 118 bp | At TSS Multiome | 990 | |
| chr4:99,088,011–99,089,765 | 827.4 kb | Distal (>10kb) Multiome HiCAR | 875 |
Genomic view of the RAP1GDS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.