Enables DNA binding activity. Involved in intracellular signal transduction; positive regulation of DNA-templated transcription; and positive regulation of apoptotic process. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for QRICH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = QRICH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of QRICH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:48,847,059–48,848,224 | 246.3 kb | Distal (>10kb) Multiome | 772 | |
| chr3:48,898,423–48,899,110 | 195.2 kb | Distal (>10kb) Multiome | 739 | |
| chr3:48,918,234–48,919,609 | 175.2 kb | Distal (>10kb) Multiome | 877 | |
| chr3:48,989,537–48,991,069 | 104.0 kb | Distal (>10kb) Multiome | 552 | |
| chr3:49,003,975–49,004,995 | 89.6 kb | Distal (>10kb) Multiome | 209 | |
| chr3:49,006,738–49,008,496 | 86.1 kb | Distal (>10kb) Multiome | 955 | |
| chr3:49,017,789–49,018,870 | 75.6 kb | Distal (>10kb) Multiome | 780 | |
| chr3:49,020,066–49,022,597 | 72.3 kb | Distal (>10kb) Multiome | 1064 | |
| chr3:49,028,856–49,029,800 | 64.6 kb | Distal (>10kb) Multiome | 974 | |
| chr3:49,093,005–49,094,956 | 234 bp | At TSS Multiome | 944 | |
| chr3:49,104,279–49,105,309 | 10.7 kb | Distal (>10kb) Multiome | 712 | |
| chr3:49,120,575–49,121,282 | 26.9 kb | Distal (>10kb) Multiome | 765 | |
| chr3:49,132,603–49,133,965 | 39.7 kb | Distal (>10kb) Multiome | 652 | |
| chr3:49,166,057–49,166,586 | 72.3 kb | Distal (>10kb) Multiome | 622 | |
| chr3:49,170,896–49,171,950 | 77.3 kb | Distal (>10kb) Multiome | 781 | |
| chr3:49,276,912–49,277,398 | 183.0 kb | Distal (>10kb) Multiome | 291 | |
| chr3:49,339,607–49,340,853 | 246.1 kb | Distal (>10kb) Multiome | 1044 | |
| chr3:49,357,868–49,359,083 | 264.4 kb | Distal (>10kb) Multiome | 908 |
Genomic view of the QRICH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.