This gene was initially characterized in human as having high expression levels in breast carcinomas and breast cancer cell lines. This gene also has increased expression in prostrate cancer cells relative to normal prostrate tissues. Expression of this gene is negatively regulated by direct binding of the microRNA miR-195 to its 3' UTR. miR-195 has been shown to modulate the invasiveness of prostrate cancer cells and xenograft metastases by downgrading expression of this gene. In mouse, the protein encoded by this gene was identified as an antigen on acute monocytic leukemia cells. In human, alternative splicing results in multiple transcript variants encoding distinct isoforms; some of these isoforms are predicted to contain an RNA pol II promoter FMP27 protein domain and a Golgi-body-localization APT1 domain. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for BLTP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BLTP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BLTP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:28,357,059–28,357,929 | 287.6 kb | Distal (>10kb) Multiome | 878 | |
| chr17:28,371,118–28,372,519 | 273.6 kb | Distal (>10kb) Multiome | 532 | |
| chr17:28,381,316–28,381,844 | 263.6 kb | Distal (>10kb) Multiome | 159 | |
| chr17:28,405,673–28,406,384 | 239.2 kb | Distal (>10kb) Multiome | 591 | |
| chr17:28,466,531–28,467,034 | 178.4 kb | Distal (>10kb) Multiome | 179 | |
| chr17:28,551,965–28,553,140 | 92.5 kb | Distal (>10kb) Multiome | 557 | |
| chr17:28,570,861–28,571,983 | 73.6 kb | Distal (>10kb) Multiome | 701 | |
| chr17:28,576,649–28,577,524 | 68.2 kb | Distal (>10kb) Multiome | 652 | |
| chr17:28,598,491–28,599,842 | 46.0 kb | Distal (>10kb) Multiome | 810 | |
| chr17:28,621,936–28,622,562 | 22.8 kb | Distal (>10kb) Multiome | 55 | |
| chr17:28,644,541–28,645,596 | 65 bp | At TSS Multiome | 795 | |
| chr17:28,661,635–28,662,527 | 17.0 kb | Distal (>10kb) Multiome | 809 | |
| chr17:28,710,720–28,712,813 | 66.3 kb | Distal (>10kb) Multiome | 892 | |
| chr17:28,717,030–28,718,784 | 72.7 kb | Distal (>10kb) Multiome | 492 | |
| chr17:28,718,918–28,720,313 | 74.6 kb | Distal (>10kb) Multiome | 927 | |
| chr17:28,724,652–28,729,474 | 81.9 kb | Distal (>10kb) Multiome | 1286 | |
| chr17:28,743,083–28,744,926 | 98.9 kb | Distal (>10kb) Multiome | 991 | |
| chr17:28,745,076–28,746,436 | 100.5 kb | Distal (>10kb) Multiome | 568 | |
| chr17:28,749,859–28,750,549 | 105.1 kb | Distal (>10kb) Multiome | 550 | |
| chr17:28,811,615–28,812,945 | 167.3 kb | Distal (>10kb) Multiome | 699 | |
| chr17:28,842,307–28,843,098 | 197.6 kb | Distal (>10kb) Multiome | 717 | |
| chr17:28,854,460–28,855,289 | 209.8 kb | Distal (>10kb) Multiome | 780 | |
| chr17:28,896,962–28,898,028 | 252.4 kb | Distal (>10kb) Multiome | 846 | |
| chr17:28,902,302–28,903,488 | 257.9 kb | Distal (>10kb) Multiome | 967 |
Genomic view of the BLTP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.