This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for DOCK6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DOCK6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DOCK6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:11,089,041–11,091,015 | 173.2 kb | Distal (>10kb) Multiome | 964 | |
| chr19:11,137,551–11,138,233 | 124.6 kb | Distal (>10kb) Multiome | 584 | |
| chr19:11,155,520–11,156,298 | 106.6 kb | Distal (>10kb) Multiome | 754 | |
| chr19:11,196,759–11,198,184 | 64.8 kb | Distal (>10kb) Multiome | 728 | |
| chr19:11,243,345–11,243,968 | 19.0 kb | Distal (>10kb) Multiome | 448 | |
| chr19:11,262,060–11,262,653 | 27 bp | At TSS Multiome | 406 | |
| chr19:11,339,100–11,339,837 | 77.2 kb | Distal (>10kb) Multiome | 506 | |
| chr19:11,346,053–11,346,958 | 84.0 kb | Distal (>10kb) Multiome | 676 | |
| chr19:11,355,078–11,355,735 | 92.9 kb | Distal (>10kb) Multiome | 382 | |
| chr19:11,361,368–11,362,625 | 99.2 kb | Distal (>10kb) Multiome | 256 | |
| chr19:11,374,474–11,375,717 | 112.5 kb | Distal (>10kb) Multiome | 866 | |
| chr19:11,380,761–11,382,262 | 118.9 kb | Distal (>10kb) Multiome | 798 | |
| chr19:11,382,830–11,384,509 | 121.9 kb | Distal (>10kb) Multiome | 761 | |
| chr19:11,418,061–11,419,498 | 156.1 kb | Distal (>10kb) Multiome | 421 | |
| chr19:11,420,614–11,422,979 | 159.7 kb | Distal (>10kb) Multiome | 507 | |
| chr19:11,434,817–11,436,365 | 172.9 kb | Distal (>10kb) Multiome | 927 | |
| chr19:11,479,217–11,480,146 | 217.2 kb | Distal (>10kb) Multiome | 394 | |
| chr19:11,481,847–11,483,040 | 220.2 kb | Distal (>10kb) Multiome | 938 | |
| chr19:11,504,741–11,506,612 | 242.9 kb | Distal (>10kb) Multiome | 854 | |
| chr19:11,528,581–11,529,391 | 266.6 kb | Distal (>10kb) Multiome | 866 | |
| chr19:11,535,847–11,536,353 | 273.7 kb | Distal (>10kb) Multiome | 694 | |
| chr19:11,538,464–11,539,111 | 276.3 kb | Distal (>10kb) Multiome | 235 | |
| chr19:11,539,738–11,540,434 | 277.6 kb | Distal (>10kb) Multiome | 176 | |
| chr19:11,558,908–11,559,777 | 296.8 kb | Distal (>10kb) Multiome | 686 |
Genomic view of the DOCK6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.