This gene encodes a tetratricopeptide repeat containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Transcription factors with Perturb-seq knockdown data for ANAPC7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANAPC7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANAPC7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:110,048,083–110,048,797 | 355.1 kb | Distal (>10kb) Multiome HiCAR | 921 | |
| chr12:110,107,883–110,108,523 | 295.5 kb | Distal (>10kb) Multiome HiCAR | 171 | |
| chr12:110,123,690–110,124,996 | 279.4 kb | Distal (>10kb) Multiome | 704 | |
| chr12:110,223,831–110,224,526 | 179.7 kb | Distal (>10kb) Multiome | 199 | |
| chr12:110,280,425–110,282,158 | 122.5 kb | Distal (>10kb) Multiome | 888 | |
| chr12:110,403,190–110,403,822 | 57 bp | At TSS Multiome | 779 | |
| chr12:110,404,015–110,404,384 | 326 bp | At TSS | 447 | |
| chr12:110,407,933–110,408,192 | 4.2 kb | Proximal (<10kb) | 6 | |
| chr12:110,409,567–110,409,803 | 5.9 kb | Proximal (<10kb) | 7 | |
| chr12:110,431,453–110,431,925 | 28.0 kb | Distal (>10kb) Multiome | 461 | |
| chr12:110,449,732–110,450,544 | 46.6 kb | Distal (>10kb) Multiome HiCAR | 883 | |
| chr12:110,468,018–110,469,597 | 65.6 kb | Distal (>10kb) Multiome | 1093 | |
| chr12:110,501,642–110,502,585 | 98.5 kb | Distal (>10kb) Multiome | 1115 | |
| chr12:110,582,284–110,583,969 | 179.7 kb | Distal (>10kb) Multiome | 740 | |
| chr12:110,613,705–110,614,482 | 210.4 kb | Distal (>10kb) Multiome | 791 | |
| chr12:110,688,496–110,690,180 | 285.6 kb | Distal (>10kb) Multiome | 414 |
Genomic view of the ANAPC7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.