Transcription factors with Perturb-seq knockdown data for ENSG00000227681. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000227681 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000227681, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:147,651,268–147,651,703 | 9.0 kb | Proximal (<10kb) | 78 | |
| chr6:147,664,043–147,664,435 | 3.3 kb | Proximal (<10kb) | 35 | |
| chr6:147,666,376–147,666,621 | 5.7 kb | Proximal (<10kb) | 17 | |
| chr6:147,666,799–147,667,203 | 6.1 kb | Proximal (<10kb) | 12 |
Genomic view of the ENSG00000227681 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.