This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for WASL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WASL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WASL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:123,533,937–123,535,843 | 214.2 kb | Distal (>10kb) Multiome | 560 | |
| chr7:123,557,224–123,558,428 | 191.1 kb | Distal (>10kb) Multiome | 732 | |
| chr7:123,594,565–123,595,316 | 154.1 kb | Distal (>10kb) Multiome | 183 | |
| chr7:123,637,247–123,638,386 | 111.0 kb | Distal (>10kb) Multiome | 95 | |
| chr7:123,657,889–123,659,811 | 90.6 kb | Distal (>10kb) Multiome | 165 | |
| chr7:123,692,360–123,692,863 | 56.3 kb | Distal (>10kb) Multiome | 179 | |
| chr7:123,747,604–123,749,779 | 141 bp | At TSS Multiome | 1065 | |
| chr7:124,031,863–124,034,280 | 283.7 kb | Distal (>10kb) Multiome | 500 |
Genomic view of the WASL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.