Enables identical protein binding activity. Involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Acts upstream of or within mitotic cytokinesis. Located in Flemming body and centrosome. Implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CEP55. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP55 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP55, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:93,198,100–93,199,722 | 298.0 kb | Distal (>10kb) Multiome | 323 | |
| chr10:93,248,667–93,249,274 | 247.7 kb | Distal (>10kb) Multiome | 252 | |
| chr10:93,252,728–93,253,353 | 243.5 kb | Distal (>10kb) Multiome | 21 | |
| chr10:93,272,746–93,273,707 | 223.4 kb | Distal (>10kb) Multiome | 280 | |
| chr10:93,280,194–93,281,735 | 215.7 kb | Distal (>10kb) Multiome | 353 | |
| chr10:93,305,125–93,305,605 | 191.3 kb | Distal (>10kb) Multiome | 88 | |
| chr10:93,316,753–93,317,413 | 179.5 kb | Distal (>10kb) Multiome | 114 | |
| chr10:93,333,260–93,334,502 | 162.9 kb | Distal (>10kb) Multiome | 227 | |
| chr10:93,438,424–93,439,283 | 57.7 kb | Distal (>10kb) Multiome | 284 | |
| chr10:93,440,320–93,441,000 | 55.9 kb | Distal (>10kb) Multiome | 170 | |
| chr10:93,445,505–93,446,138 | 50.8 kb | Distal (>10kb) Multiome | 524 | |
| chr10:93,494,134–93,494,978 | 2.0 kb | Proximal (<10kb) Multiome | 27 | |
| chr10:93,495,692–93,496,987 | 137 bp | At TSS Multiome | 785 | |
| chr10:93,566,315–93,567,350 | 70.2 kb | Distal (>10kb) Multiome | 301 | |
| chr10:93,702,336–93,703,002 | 206.0 kb | Distal (>10kb) Multiome | 1036 | |
| chr10:93,748,844–93,749,704 | 252.7 kb | Distal (>10kb) Multiome | 214 |
Genomic view of the CEP55 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.