AURKB
aurora kinase B | AIM-1, ARK2, Aik2, AurB, IPL1, PPP1R48, STK5, STK12

This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]

Member of: DE-11 DE-11.1
Biological processes 87 terms
ATP binding (GO:0005524)cell cycle G2/M phase transition (GO:0044839)cell cycle G2/M phase transition (GO:0044839)cellular response to UV (GO:0034644)centrosome (GO:0005813)chromatin (GO:0000785)chromatin remodeling (GO:0006338)chromocenter (GO:0010369)chromosome (GO:0005694)chromosome passenger complex (GO:0032133)chromosome passenger complex (GO:0032133)chromosome passenger complex (GO:0032133)chromosome passenger complex (GO:0032133)chromosome, centromeric region (GO:0000775)cleavage furrow formation (GO:0036089)cleavage furrow formation (GO:0036089)condensed chromosome, centromeric region (GO:0000779)condensed chromosome, centromeric region (GO:0000779)cytosol (GO:0005829)histone H1-4S27 kinase activity (GO:0140197)kinase binding (GO:0019900)kinetochore (GO:0000776)kinetochore (GO:0000776)kinetochore (GO:0000776)microtubule cytoskeleton (GO:0015630)midbody (GO:0030496)midbody (GO:0030496)midbody (GO:0030496)midbody (GO:0030496)midbody abscission (GO:0061952)mitotic cell cycle (GO:0000278)mitotic cytokinesis (GO:0000281)mitotic cytokinesis checkpoint signaling (GO:0044878)mitotic sister chromatid biorientation (GO:1990758)mitotic spindle assembly (GO:0090307)mitotic spindle midzone (GO:1990023)mitotic spindle midzone assembly (GO:0051256)mitotic spindle midzone assembly (GO:0051256)mitotic spindle midzone assembly (GO:0051256)mitotic spindle organization (GO:0007052)mitotic spindle pole (GO:0097431)negative regulation of B cell apoptotic process (GO:0002903)negative regulation of cGAS/STING signaling pathway (GO:0160049)negative regulation of cytokinesis (GO:0032466)negative regulation of innate immune response (GO:0045824)negative regulation of protein localization to chromatin (GO:0120186)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of attachment of mitotic spindle microtubules to kinetochore (GO:1902425)positive regulation of cell cycle process (GO:0090068)positive regulation of cytokinesis (GO:0032467)positive regulation of cytokinesis (GO:0032467)positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore (GO:1905116)positive regulation of microtubule depolymerization (GO:0031117)positive regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090267)positive regulation of mitotic cytokinesis (GO:1903490)positive regulation of mitotic sister chromatid segregation (GO:0062033)positive regulation of mitotic sister chromatid separation (GO:1901970)positive regulation of telomere maintenance (GO:0032206)post-translational protein modification (GO:0043687)post-translational protein modification (GO:0043687)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein localization to kinetochore (GO:0034501)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine/tyrosine kinase activity (GO:0004712)protein serine/threonine/tyrosine kinase activity (GO:0004712)regulation of chromosome segregation (GO:0051983)regulation of cytokinesis (GO:0032465)regulation of microtubule-based process (GO:0032886)regulation of signal transduction by p53 class mediator (GO:1901796)regulation of signal transduction by p53 class mediator (GO:1901796)repair of mitotic kinetochore microtubule attachment defect (GO:0140273)spindle (GO:0005819)spindle (GO:0005819)spindle microtubule (GO:0005876)spindle midzone (GO:0051233)spindle organization (GO:0007051)spindle pole (GO:0000922)
Expression (TPM)
AURKB — as a Regulated Gene

TFs regulating AURKB 0 TFs

Transcription factors with Perturb-seq knockdown data for AURKB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AURKB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to AURKB

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AURKB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:7,915,430–7,916,499 294.7 kb Distal (>10kb) Multiome 869
chr17:7,922,863–7,923,421 287.6 kb Distal (>10kb) Multiome 205
chr17:7,929,559–7,930,172 280.8 kb Distal (>10kb) Multiome 106
chr17:7,931,533–7,932,876 278.5 kb Distal (>10kb) Multiome 767
chr17:7,971,685–7,972,375 238.7 kb Distal (>10kb) Multiome 45
chr17:7,989,908–7,990,676 220.3 kb Distal (>10kb) Multiome 652
chr17:8,015,966–8,016,968 194.6 kb Distal (>10kb) Multiome 339
chr17:8,068,609–8,069,844 141.8 kb Distal (>10kb) Multiome 100
chr17:8,079,261–8,080,640 131.1 kb Distal (>10kb) Multiome 613
chr17:8,109,567–8,110,530 100.3 kb Distal (>10kb) Multiome 360
chr17:8,117,780–8,119,396 91.6 kb Distal (>10kb) Multiome 684
chr17:8,119,590–8,122,560 90.0 kb Distal (>10kb) Multiome 968
chr17:8,123,407–8,124,386 86.5 kb Distal (>10kb) Multiome 296
chr17:8,125,308–8,126,995 84.9 kb Distal (>10kb) Multiome 724
chr17:8,138,425–8,139,804 71.6 kb Distal (>10kb) Multiome 981
chr17:8,151,026–8,151,640 59.4 kb Distal (>10kb) Multiome 435
chr17:8,151,914–8,152,786 58.1 kb Distal (>10kb) Multiome 633
chr17:8,153,878–8,154,864 56.2 kb Distal (>10kb) Multiome 644
chr17:8,155,928–8,157,418 54.0 kb Distal (>10kb) Multiome 789
chr17:8,162,377–8,163,907 47.5 kb Distal (>10kb) Multiome 637
chr17:8,172,460–8,174,346 37.1 kb Distal (>10kb) Multiome 1196
chr17:8,175,900–8,176,943 34.2 kb Distal (>10kb) Multiome 601
chr17:8,185,937–8,188,084 22.9 kb Distal (>10kb) Multiome 1065
chr17:8,189,376–8,190,688 20.3 kb Distal (>10kb) Multiome 748
chr17:8,192,025–8,192,719 18.2 kb Distal (>10kb) Multiome 452
chr17:8,210,139–8,210,786 17 bp At TSS Multiome 778
chr17:8,220,148–8,220,526 9.5 kb Proximal (<10kb) 201
chr17:8,220,662–8,224,088 12.4 kb Distal (>10kb) Multiome 1171
chr17:8,226,529–8,227,280 16.2 kb Distal (>10kb) Multiome 565
chr17:8,247,519–8,249,589 38.7 kb Distal (>10kb) Multiome 914
chr17:8,288,100–8,289,230 78.2 kb Distal (>10kb) Multiome 751
chr17:8,295,073–8,296,021 84.9 kb Distal (>10kb) Multiome 739
chr17:8,310,033–8,310,555 99.7 kb Distal (>10kb) Multiome 98
chr17:8,313,329–8,313,824 103.0 kb Distal (>10kb) Multiome 30
chr17:8,376,215–8,376,918 166.1 kb Distal (>10kb) Multiome 888
chr17:8,382,925–8,384,028 172.8 kb Distal (>10kb) Multiome 981
chr17:8,435,307–8,436,885 225.3 kb Distal (>10kb) Multiome 847

Genome Browser

Genomic view of the AURKB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:7,905,430 – 8,446,885
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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