The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). The encoded protein is necessary for proper control of the G2/M transition phase of the cell cycle. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for CCNB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCNB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCNB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:68,922,292–68,922,890 | 244.6 kb | Distal (>10kb) Multiome | 63 | |
| chr5:69,093,377–69,094,772 | 73.2 kb | Distal (>10kb) Multiome | 952 | |
| chr5:69,166,575–69,167,819 | 97 bp | At TSS Multiome | 840 | |
| chr5:69,188,979–69,190,115 | 22.5 kb | Distal (>10kb) Multiome | 898 | |
| chr5:69,217,542–69,218,587 | 50.8 kb | Distal (>10kb) Multiome | 898 | |
| chr5:69,234,302–69,235,305 | 67.7 kb | Distal (>10kb) Multiome | 732 | |
| chr5:69,300,544–69,301,286 | 133.7 kb | Distal (>10kb) Multiome | 217 | |
| chr5:69,368,998–69,370,235 | 202.5 kb | Distal (>10kb) Multiome | 956 | |
| chr5:69,414,852–69,415,897 | 248.0 kb | Distal (>10kb) Multiome | 714 |
Genomic view of the CCNB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.