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DE-1.20

Submodule 20 genes

RNA binding and vesicular trafficking processes

This module contains 20 genes including ELAVL1, SMARCB1, GFER, and RAB8A, with enrichment in RNA binding, chromatin remodeling, and vesicular transport. Knockdown of ZC3H3 activates this module. No repressing transcription factors were identified.

Key terms: nucleic acid metabolic process RNA metabolic process nucleobase-containing compound metabolic process regulation of stem cell population maintenance Notable genes: ELAVL1 SMARCB1 GFER RAB8A HYAL2 MCRS1 TSN THAP11 Top TFs: ZC3H3

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (20)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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