This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for TSN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TSN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TSN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:121,529,786–121,532,189 | 224.8 kb | Distal (>10kb) Multiome | 1343 | |
| chr2:121,648,584–121,650,422 | 106.0 kb | Distal (>10kb) Multiome | 1043 | |
| chr2:121,680,120–121,680,609 | 75.3 kb | Distal (>10kb) Multiome | 87 | |
| chr2:121,736,354–121,737,978 | 18.6 kb | Distal (>10kb) Multiome | 878 | |
| chr2:121,745,785–121,746,842 | 9.3 kb | Proximal (<10kb) Multiome | 195 | |
| chr2:121,754,998–121,756,033 | 80 bp | At TSS Multiome | 944 |
Genomic view of the TSN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.