The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]
Transcription factors with Perturb-seq knockdown data for ELAVL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELAVL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELAVL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:7,829,238–7,830,666 | 175.8 kb | Distal (>10kb) Multiome | 621 | |
| chr19:7,853,168–7,853,781 | 152.2 kb | Distal (>10kb) Multiome | 747 | |
| chr19:7,861,607–7,864,383 | 142.9 kb | Distal (>10kb) Multiome | 348 | |
| chr19:7,868,454–7,870,252 | 136.2 kb | Distal (>10kb) Multiome | 721 | |
| chr19:7,871,072–7,872,772 | 133.5 kb | Distal (>10kb) Multiome | 487 | |
| chr19:7,873,962–7,875,061 | 131.0 kb | Distal (>10kb) Multiome | 416 | |
| chr19:7,888,334–7,888,798 | 117.2 kb | Distal (>10kb) Multiome | 509 | |
| chr19:7,902,730–7,904,931 | 101.9 kb | Distal (>10kb) Multiome | 1000 | |
| chr19:7,917,358–7,918,182 | 87.7 kb | Distal (>10kb) Multiome | 316 | |
| chr19:7,919,934–7,921,640 | 85.0 kb | Distal (>10kb) Multiome | 802 | |
| chr19:7,924,612–7,926,698 | 80.4 kb | Distal (>10kb) Multiome | 766 | |
| chr19:7,943,338–7,944,472 | 61.8 kb | Distal (>10kb) Multiome | 974 | |
| chr19:8,001,954–8,002,874 | 3.2 kb | Proximal (<10kb) Multiome | 475 | |
| chr19:8,005,202–8,006,197 | 66 bp | At TSS Multiome | 729 | |
| chr19:8,028,908–8,029,518 | 23.7 kb | Distal (>10kb) Multiome | 122 | |
| chr19:8,050,174–8,051,154 | 45.0 kb | Distal (>10kb) Multiome | 467 | |
| chr19:8,148,316–8,149,986 | 143.8 kb | Distal (>10kb) Multiome | 381 | |
| chr19:8,203,277–8,204,384 | 198.2 kb | Distal (>10kb) Multiome | 150 | |
| chr19:8,208,086–8,210,178 | 203.5 kb | Distal (>10kb) Multiome | 712 | |
| chr19:8,268,737–8,269,370 | 263.3 kb | Distal (>10kb) Multiome | 272 |
Genomic view of the ELAVL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.