Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF486. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF486 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF486, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:19,866,439–19,867,170 | 300.2 kb | Distal (>10kb) Multiome | 306 | |
| chr19:19,900,670–19,901,891 | 266.3 kb | Distal (>10kb) Multiome | 405 | |
| chr19:20,038,984–20,039,716 | 127.7 kb | Distal (>10kb) Multiome | 495 | |
| chr19:20,051,726–20,052,860 | 115.0 kb | Distal (>10kb) Multiome | 402 | |
| chr19:20,066,768–20,067,242 | 100.2 kb | Distal (>10kb) Multiome | 8 | |
| chr19:20,067,957–20,069,262 | 98.3 kb | Distal (>10kb) Multiome | 17 | |
| chr19:20,077,737–20,078,423 | 89.3 kb | Distal (>10kb) Multiome | 212 | |
| chr19:20,082,410–20,083,233 | 84.4 kb | Distal (>10kb) Multiome | 155 | |
| chr19:20,166,957–20,167,632 | 17 bp | At TSS Multiome | 222 | |
| chr19:20,237,984–20,238,687 | 71.3 kb | Distal (>10kb) Multiome | 188 | |
| chr19:20,261,348–20,261,810 | 94.4 kb | Distal (>10kb) Multiome | 44 | |
| chr19:20,285,651–20,286,726 | 118.9 kb | Distal (>10kb) Multiome | 95 | |
| chr19:20,367,718–20,368,350 | 200.9 kb | Distal (>10kb) Multiome | 103 | |
| chr19:20,371,834–20,372,343 | 204.8 kb | Distal (>10kb) Multiome | 96 | |
| chr19:20,424,664–20,425,178 | 257.7 kb | Distal (>10kb) Multiome | 133 |
Genomic view of the ZNF486 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.