Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be active in chromatin. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for VRTN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = VRTN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of VRTN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:74,083,828–74,085,467 | 263.8 kb | Distal (>10kb) Multiome | 824 | |
| chr14:74,257,088–74,257,807 | 90.8 kb | Distal (>10kb) Multiome | 415 | |
| chr14:74,302,423–74,303,735 | 45.4 kb | Distal (>10kb) Multiome | 863 | |
| chr14:74,326,054–74,327,644 | 21.7 kb | Distal (>10kb) Multiome | 320 | |
| chr14:74,347,561–74,349,516 | 161 bp | At TSS Multiome | 231 | |
| chr14:74,349,652–74,350,519 | 1.2 kb | Proximal (<10kb) | 61 | |
| chr14:74,350,632–74,350,973 | 2.2 kb | Proximal (<10kb) | 52 | |
| chr14:74,362,136–74,363,080 | 14.1 kb | Distal (>10kb) Multiome | 318 | |
| chr14:74,392,794–74,393,544 | 44.7 kb | Distal (>10kb) Multiome | 159 | |
| chr14:74,417,196–74,418,934 | 69.5 kb | Distal (>10kb) Multiome | 153 | |
| chr14:74,425,677–74,426,474 | 77.6 kb | Distal (>10kb) Multiome | 342 | |
| chr14:74,442,382–74,443,260 | 94.2 kb | Distal (>10kb) Multiome | 53 | |
| chr14:74,470,530–74,471,370 | 122.4 kb | Distal (>10kb) Multiome HiCAR | 31 | |
| chr14:74,492,838–74,494,443 | 145.1 kb | Distal (>10kb) Multiome HiCAR | 820 | |
| chr14:74,500,815–74,501,591 | 152.7 kb | Distal (>10kb) Multiome | 179 | |
| chr14:74,611,325–74,612,912 | 264.2 kb | Distal (>10kb) Multiome | 552 | |
| chr14:74,620,601–74,621,179 | 272.4 kb | Distal (>10kb) Multiome | 257 |
Genomic view of the VRTN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.