The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Transcription factors with Perturb-seq knockdown data for SLC39A7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC39A7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC39A7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:32,952,883–32,953,496 | 247.6 kb | Distal (>10kb) Multiome | 366 | |
| chr6:32,967,972–32,971,214 | 232.1 kb | Distal (>10kb) Multiome | 1227 | |
| chr6:32,971,467–32,973,408 | 228.8 kb | Distal (>10kb) Multiome | 1115 | |
| chr6:33,009,348–33,009,899 | 191.2 kb | Distal (>10kb) Multiome | 184 | |
| chr6:33,080,635–33,081,087 | 120.2 kb | Distal (>10kb) Multiome | 141 | |
| chr6:33,161,505–33,162,100 | 39.1 kb | Distal (>10kb) Multiome | 589 | |
| chr6:33,192,178–33,192,623 | 8.2 kb | Proximal (<10kb) | 84 | |
| chr6:33,197,559–33,197,971 | 2.9 kb | Proximal (<10kb) | 298 | |
| chr6:33,199,801–33,201,289 | 165 bp | At TSS Multiome | 1049 | |
| chr6:33,204,263–33,205,422 | 3.8 kb | Proximal (<10kb) Multiome | 762 | |
| chr6:33,207,796–33,208,014 | 7.0 kb | Proximal (<10kb) | 349 | |
| chr6:33,208,069–33,208,990 | 7.8 kb | Proximal (<10kb) Multiome | 858 | |
| chr6:33,248,132–33,249,983 | 47.5 kb | Distal (>10kb) Multiome | 961 | |
| chr6:33,271,370–33,272,508 | 71.1 kb | Distal (>10kb) Multiome | 1058 | |
| chr6:33,276,685–33,277,905 | 76.6 kb | Distal (>10kb) Multiome | 807 | |
| chr6:33,288,941–33,289,881 | 88.6 kb | Distal (>10kb) Multiome | 701 | |
| chr6:33,297,445–33,300,232 | 97.0 kb | Distal (>10kb) Multiome | 1095 | |
| chr6:33,312,436–33,314,207 | 112.1 kb | Distal (>10kb) Multiome | 795 | |
| chr6:33,317,189–33,318,504 | 117.1 kb | Distal (>10kb) Multiome | 649 | |
| chr6:33,322,636–33,323,832 | 122.3 kb | Distal (>10kb) Multiome | 941 | |
| chr6:33,346,609–33,347,126 | 146.0 kb | Distal (>10kb) Multiome | 37 | |
| chr6:33,390,888–33,392,247 | 190.8 kb | Distal (>10kb) Multiome | 993 | |
| chr6:33,409,936–33,411,502 | 209.7 kb | Distal (>10kb) Multiome | 977 | |
| chr6:33,417,606–33,419,249 | 217.4 kb | Distal (>10kb) Multiome | 973 | |
| chr6:33,419,793–33,420,532 | 219.4 kb | Distal (>10kb) Multiome | 162 | |
| chr6:33,425,590–33,426,362 | 225.1 kb | Distal (>10kb) Multiome | 665 | |
| chr6:33,431,024–33,432,096 | 230.4 kb | Distal (>10kb) Multiome | 337 | |
| chr6:33,454,074–33,454,852 | 253.7 kb | Distal (>10kb) Multiome | 906 |
Genomic view of the SLC39A7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.