Enables histone H3 methyltransferase activity; p53 binding activity; and protein-lysine N-methyltransferase activity. Involved in peptidyl-lysine dimethylation and peptidyl-lysine monomethylation. Acts upstream of or within DNA damage response and heterochromatin organization. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SETD7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SETD7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SETD7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:139,020,400–139,021,056 | 535.6 kb | Distal (>10kb) Multiome HiCAR | 167 | |
| chr4:139,279,361–139,280,628 | 276.0 kb | Distal (>10kb) Multiome | 287 | |
| chr4:139,295,267–139,296,002 | 260.4 kb | Distal (>10kb) Multiome | 947 | |
| chr4:139,300,735–139,302,627 | 254.9 kb | Distal (>10kb) Multiome | 912 | |
| chr4:139,453,063–139,454,584 | 102.4 kb | Distal (>10kb) Multiome | 989 | |
| chr4:139,550,863–139,551,333 | 4.9 kb | Proximal (<10kb) | 87 | |
| chr4:139,551,444–139,551,655 | 4.6 kb | Proximal (<10kb) | 47 | |
| chr4:139,554,508–139,554,649 | 1.6 kb | Proximal (<10kb) | 24 | |
| chr4:139,555,161–139,557,952 | 823 bp | At TSS Multiome | 818 | |
| chr4:139,560,398–139,560,695 | 4.2 kb | Proximal (<10kb) | 71 | |
| chr4:139,656,647–139,657,308 | 100.8 kb | Distal (>10kb) Multiome | 322 | |
| chr4:139,665,282–139,666,449 | 109.6 kb | Distal (>10kb) Multiome | 844 | |
| chr4:139,667,275–139,669,052 | 112.1 kb | Distal (>10kb) Multiome | 181 | |
| chr4:139,669,155–139,671,298 | 113.7 kb | Distal (>10kb) Multiome | 252 | |
| chr4:139,734,753–139,735,998 | 178.9 kb | Distal (>10kb) Multiome | 441 | |
| chr4:139,815,781–139,816,678 | 260.1 kb | Distal (>10kb) Multiome | 288 | |
| chr4:139,853,016–139,854,104 | 297.3 kb | Distal (>10kb) Multiome | 227 |
Genomic view of the SETD7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.