This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for PRC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:90,716,853–90,717,827 | 277.3 kb | Distal (>10kb) Multiome | 824 | |
| chr15:90,839,491–90,840,162 | 154.8 kb | Distal (>10kb) Multiome | 261 | |
| chr15:90,883,883–90,884,953 | 110.1 kb | Distal (>10kb) Multiome | 304 | |
| chr15:90,902,271–90,903,624 | 91.9 kb | Distal (>10kb) Multiome | 817 | |
| chr15:90,931,729–90,933,077 | 62.6 kb | Distal (>10kb) Multiome | 926 | |
| chr15:90,934,164–90,935,936 | 59.3 kb | Distal (>10kb) Multiome | 701 | |
| chr15:90,954,493–90,955,641 | 39.6 kb | Distal (>10kb) Multiome | 974 | |
| chr15:90,956,070–90,957,754 | 37.8 kb | Distal (>10kb) Multiome | 410 | |
| chr15:90,994,023–90,995,142 | 179 bp | At TSS Multiome | 929 | |
| chr15:91,021,873–91,022,829 | 28.0 kb | Distal (>10kb) Multiome | 735 | |
| chr15:91,032,872–91,033,463 | 38.7 kb | Distal (>10kb) Multiome | 347 | |
| chr15:91,099,400–91,100,613 | 105.7 kb | Distal (>10kb) Multiome | 351 | |
| chr15:91,101,202–91,101,847 | 107.0 kb | Distal (>10kb) Multiome | 48 | |
| chr15:91,140,477–91,140,966 | 146.2 kb | Distal (>10kb) Multiome | 31 | |
| chr15:91,202,218–91,202,996 | 208.2 kb | Distal (>10kb) Multiome | 29 |
Genomic view of the PRC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.