This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for NXN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NXN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NXN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:714,554–715,298 | 264.9 kb | Distal (>10kb) Multiome | 798 | |
| chr17:731,870–733,144 | 247.4 kb | Distal (>10kb) Multiome | 602 | |
| chr17:751,539–752,928 | 227.5 kb | Distal (>10kb) Multiome | 891 | |
| chr17:781,922–782,799 | 197.5 kb | Distal (>10kb) Multiome HiCAR | 914 | |
| chr17:875,256–875,758 | 104.3 kb | Distal (>10kb) Multiome HiCAR | 42 | |
| chr17:927,652–928,423 | 51.9 kb | Distal (>10kb) Multiome | 315 | |
| chr17:933,255–933,971 | 46.2 kb | Distal (>10kb) Multiome | 400 | |
| chr17:951,413–952,178 | 28.0 kb | Distal (>10kb) Multiome | 385 | |
| chr17:964,907–965,931 | 14.2 kb | Distal (>10kb) Multiome | 256 | |
| chr17:978,189–980,530 | 61 bp | At TSS Multiome | 639 | |
| chr17:981,043–981,329 | 1.3 kb | Proximal (<10kb) | 332 | |
| chr17:996,479–997,532 | 17.1 kb | Distal (>10kb) Multiome | 994 | |
| chr17:1,031,608–1,032,193 | 52.1 kb | Distal (>10kb) Multiome | 54 | |
| chr17:1,109,073–1,109,822 | 129.8 kb | Distal (>10kb) Multiome | 401 | |
| chr17:1,179,265–1,180,687 | 200.3 kb | Distal (>10kb) Multiome | 303 | |
| chr17:1,187,041–1,187,512 | 207.6 kb | Distal (>10kb) Multiome | 361 | |
| chr17:1,202,976–1,204,162 | 223.7 kb | Distal (>10kb) Multiome | 420 | |
| chr17:1,210,129–1,211,219 | 230.9 kb | Distal (>10kb) Multiome | 35 | |
| chr17:1,268,002–1,268,635 | 288.6 kb | Distal (>10kb) Multiome | 644 |
Genomic view of the NXN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.