Involved in several processes, including negative regulation of actin filament polymerization; negative regulation of heterotypic cell-cell adhesion; and positive regulation of substrate adhesion-dependent cell spreading. Located in several cellular components, including cortical actin cytoskeleton; membrane raft; and ruffle. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MYADM. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYADM upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYADM, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:53,594,477–53,595,909 | 270.8 kb | Distal (>10kb) Multiome | 262 | |
| chr19:53,612,802–53,613,443 | 253.2 kb | Distal (>10kb) Multiome | 182 | |
| chr19:53,772,960–53,773,600 | 93.1 kb | Distal (>10kb) Multiome | 98 | |
| chr19:53,774,097–53,775,097 | 91.6 kb | Distal (>10kb) Multiome | 24 | |
| chr19:53,792,791–53,793,343 | 73.0 kb | Distal (>10kb) Multiome | 470 | |
| chr19:53,865,880–53,866,753 | 110 bp | At TSS Multiome | 532 | |
| chr19:53,866,887–53,869,891 | 1.5 kb | Proximal (<10kb) Multiome | 993 | |
| chr19:53,878,918–53,880,011 | 13.4 kb | Distal (>10kb) Multiome | 561 | |
| chr19:53,881,744–53,882,458 | 16.0 kb | Distal (>10kb) Multiome | 435 | |
| chr19:53,889,715–53,890,286 | 23.9 kb | Distal (>10kb) Multiome | 322 | |
| chr19:53,898,176–53,899,412 | 32.8 kb | Distal (>10kb) Multiome | 212 | |
| chr19:53,907,868–53,908,722 | 42.1 kb | Distal (>10kb) Multiome | 276 | |
| chr19:53,941,849–53,943,229 | 76.3 kb | Distal (>10kb) Multiome | 240 | |
| chr19:53,957,309–53,957,858 | 91.4 kb | Distal (>10kb) Multiome | 97 | |
| chr19:53,977,539–53,979,011 | 112.3 kb | Distal (>10kb) Multiome | 412 | |
| chr19:53,979,770–53,982,403 | 115.1 kb | Distal (>10kb) Multiome | 530 | |
| chr19:53,982,560–53,983,015 | 116.7 kb | Distal (>10kb) Multiome | 119 | |
| chr19:54,095,628–54,096,220 | 229.8 kb | Distal (>10kb) Multiome | 457 | |
| chr19:54,102,597–54,103,302 | 236.7 kb | Distal (>10kb) Multiome | 703 | |
| chr19:54,114,870–54,116,009 | 249.4 kb | Distal (>10kb) Multiome | 911 | |
| chr19:54,136,562–54,138,683 | 271.2 kb | Distal (>10kb) Multiome | 751 | |
| chr19:54,159,030–54,160,865 | 293.7 kb | Distal (>10kb) Multiome | 793 | |
| chr19:54,161,897–54,162,738 | 296.3 kb | Distal (>10kb) Multiome | 233 | |
| chr19:54,164,508–54,165,013 | 298.7 kb | Distal (>10kb) Multiome | 183 |
Genomic view of the MYADM locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.