The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for KIF23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = KIF23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of KIF23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:69,059,802–69,060,199 | 354.2 kb | Distal (>10kb) Multiome HiCAR | 71 | |
| chr15:69,117,299–69,117,876 | 296.6 kb | Distal (>10kb) Multiome | 153 | |
| chr15:69,160,021–69,161,216 | 253.8 kb | Distal (>10kb) Multiome | 783 | |
| chr15:69,290,511–69,291,221 | 123.4 kb | Distal (>10kb) Multiome | 40 | |
| chr15:69,298,371–69,299,879 | 115.4 kb | Distal (>10kb) Multiome | 345 | |
| chr15:69,413,943–69,415,079 | 65 bp | At TSS Multiome | 826 | |
| chr15:69,452,178–69,453,528 | 38.5 kb | Distal (>10kb) Multiome | 983 | |
| chr15:69,462,352–69,463,273 | 48.6 kb | Distal (>10kb) Multiome | 753 | |
| chr15:69,552,979–69,553,564 | 138.9 kb | Distal (>10kb) Multiome | 56 | |
| chr15:69,554,171–69,555,109 | 140.3 kb | Distal (>10kb) Multiome | 267 | |
| chr15:69,594,118–69,595,443 | 180.5 kb | Distal (>10kb) Multiome | 716 | |
| chr15:69,603,844–69,604,478 | 189.8 kb | Distal (>10kb) Multiome | 183 |
Genomic view of the KIF23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.