HIPK2

homeodomain interacting protein kinase 2

This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Member of: DE-4 DE-4.3 Developmental clusters: GC6

Biological processes 76 terms

ATP binding (GO:0005524)DNA damage response, signal transduction by p53 class mediator (GO:0030330)PML body (GO:0016605)PML body (GO:0016605)PML body (GO:0016605)PML body organization (GO:0030578)RNA polymerase II transcription regulator complex (GO:0090575)RNA polymerase II transcription regulator complex (GO:0090575)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)SMAD binding (GO:0046332)SMAD binding (GO:0046332)SMAD protein signal transduction (GO:0060395)cellular response to hypoxia (GO:0071456)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic stress granule (GO:0010494)cytoplasmic stress granule (GO:0010494)embryonic camera-type eye morphogenesis (GO:0048596)embryonic retina morphogenesis in camera-type eye (GO:0060059)epigenetic regulation of gene expression (GO:0040029)erythrocyte differentiation (GO:0030218)eye development (GO:0001654)intrinsic apoptotic signaling pathway (GO:0097193)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)iris morphogenesis (GO:0061072)lens induction in camera-type eye (GO:0060235)negative regulation of BMP signaling pathway (GO:0030514)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of ubiquitin-dependent protein catabolic process (GO:2000059)neuron differentiation (GO:0030182)nuclear body (GO:0016604)nuclear body (GO:0016604)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)peptidyl-serine phosphorylation (GO:0018105)positive regulation of JNK cascade (GO:0046330)positive regulation of angiogenesis (GO:0045766)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein kinase activity (GO:0004672)protein phosphorylation (GO:0006468)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein tyrosine kinase activity (GO:0004713)regulation of cell cycle (GO:0051726)regulation of signal transduction by p53 class mediator (GO:1901796)retina layer formation (GO:0010842)smoothened signaling pathway (GO:0007224)transcription coactivator activity (GO:0003713)transcription coactivator activity (GO:0003713)transcription coactivator activity (GO:0003713)transcription corepressor activity (GO:0003714)transcription corepressor activity (GO:0003714)transcription corepressor activity (GO:0003714)transcription corepressor activity (GO:0003714)virion binding (GO:0046790)

Expression (TPM)

TFs regulating HIPK2 0 TFs

Transcription factors with Perturb-seq knockdown data for HIPK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HIPK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to HIPK2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HIPK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:139,482,716–139,484,133	294.3 kb	Distal (>10kb) Multiome	464
chr7:139,499,861–139,500,450	277.8 kb	Distal (>10kb) Multiome	482
chr7:139,523,378–139,524,503	254.1 kb	Distal (>10kb) Multiome	136
chr7:139,660,103–139,661,027	117.3 kb	Distal (>10kb) Multiome	329
chr7:139,777,264–139,778,898	77 bp	At TSS Multiome	657
chr7:139,783,741–139,783,987	6.0 kb	Proximal (<10kb)	60
chr7:139,829,228–139,829,956	51.6 kb	Distal (>10kb) Multiome	262
chr7:139,838,738–139,839,616	61.1 kb	Distal (>10kb) Multiome	42
chr7:139,851,513–139,852,522	74.0 kb	Distal (>10kb) Multiome	188
chr7:139,852,825–139,853,587	75.3 kb	Distal (>10kb) Multiome	278
chr7:139,971,936–139,972,384	194.2 kb	Distal (>10kb) Multiome	102
chr7:140,062,257–140,063,368	284.9 kb	Distal (>10kb) Multiome	805

Genome Browser

Genomic view of the HIPK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.