Predicted to enable calcium ion binding activity. Involved in several processes, including negative regulation of Rho protein signal transduction; negative regulation of Rho-dependent protein serine/threonine kinase activity; and negative regulation of membrane permeability. Located in cell-cell junction. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HEG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HEG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HEG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:124,757,599–124,758,508 | 298.1 kb | Distal (>10kb) Multiome | 59 | |
| chr3:124,827,544–124,828,219 | 228.2 kb | Distal (>10kb) Multiome | 128 | |
| chr3:124,886,097–124,888,040 | 168.5 kb | Distal (>10kb) Multiome | 804 | |
| chr3:124,888,393–124,889,745 | 166.8 kb | Distal (>10kb) Multiome | 135 | |
| chr3:124,910,445–124,911,085 | 145.2 kb | Distal (>10kb) Multiome | 133 | |
| chr3:125,052,193–125,052,466 | 3.5 kb | Proximal (<10kb) | 175 | |
| chr3:125,055,367–125,056,705 | 118 bp | At TSS Multiome | 524 | |
| chr3:125,057,572–125,058,037 | 1.6 kb | Proximal (<10kb) | 50 | |
| chr3:125,120,569–125,121,347 | 65.0 kb | Distal (>10kb) Multiome | 178 | |
| chr3:125,141,761–125,142,375 | 86.0 kb | Distal (>10kb) Multiome | 228 | |
| chr3:125,155,911–125,156,374 | 100.0 kb | Distal (>10kb) Multiome | 134 | |
| chr3:125,211,780–125,213,160 | 156.4 kb | Distal (>10kb) Multiome | 258 |
Genomic view of the HEG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.