Transcription factors with Perturb-seq knockdown data for ENSG00000290993. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290993 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290993, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:129,120,244–129,122,947 | 277.4 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,160,815–129,162,244 | 238.0 kb | Distal (>10kb) Multiome | 917 | |
| chr3:129,183,284–129,184,525 | 215.5 kb | Distal (>10kb) Multiome | 966 | |
| chr3:129,249,227–129,250,064 | 149.9 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,278,315–129,279,976 | 120.6 kb | Distal (>10kb) Multiome | 767 | |
| chr3:129,305,525–129,306,095 | 93.6 kb | Distal (>10kb) Multiome | 342 | |
| chr3:129,314,154–129,316,995 | 84.5 kb | Distal (>10kb) Multiome | 949 | |
| chr3:129,343,720–129,344,497 | 55.3 kb | Distal (>10kb) Multiome | 346 | |
| chr3:129,344,512–129,344,822 | 54.7 kb | Distal (>10kb) Multiome | 58 | |
| chr3:129,359,825–129,360,642 | 39.0 kb | Distal (>10kb) Multiome | 65 | |
| chr3:129,399,193–129,399,868 | 186 bp | At TSS Multiome | 625 | |
| chr3:129,428,173–129,429,050 | 29.3 kb | Distal (>10kb) Multiome | 504 | |
| chr3:129,439,426–129,440,695 | 40.8 kb | Distal (>10kb) Multiome | 875 | |
| chr3:129,534,465–129,535,515 | 135.5 kb | Distal (>10kb) Multiome | 397 | |
| chr3:129,602,230–129,602,769 | 203.1 kb | Distal (>10kb) Multiome | 70 | |
| chr3:129,605,081–129,607,497 | 207.5 kb | Distal (>10kb) Multiome | 686 | |
| chr3:129,626,284–129,628,391 | 227.4 kb | Distal (>10kb) Multiome | 862 | |
| chr3:129,699,077–129,699,564 | 299.9 kb | Distal (>10kb) Multiome | 166 |
Genomic view of the ENSG00000290993 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.