Transcription factors with Perturb-seq knockdown data for ENSG00000290888. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290888 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290888, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:3,807,895–3,808,372 | 299.6 kb | Distal (>10kb) Multiome | 54 | |
| chr4:3,847,183–3,847,841 | 260.2 kb | Distal (>10kb) Multiome | 31 | |
| chr4:3,862,359–3,863,269 | 244.8 kb | Distal (>10kb) Multiome | 188 | |
| chr4:3,871,162–3,872,292 | 235.9 kb | Distal (>10kb) Multiome | 206 | |
| chr4:3,873,427–3,873,927 | 234.1 kb | Distal (>10kb) Multiome | 50 | |
| chr4:3,880,124–3,880,883 | 226.9 kb | Distal (>10kb) Multiome | 317 | |
| chr4:3,925,756–3,926,526 | 181.4 kb | Distal (>10kb) Multiome | 7 | |
| chr4:3,927,408–3,928,004 | 179.9 kb | Distal (>10kb) Multiome | 19 | |
| chr4:3,954,698–3,956,574 | 151.8 kb | Distal (>10kb) Multiome | 434 | |
| chr4:4,048,067–4,048,621 | 59.3 kb | Distal (>10kb) Multiome | 77 | |
| chr4:4,107,312–4,107,787 | 32 bp | At TSS Multiome | 107 | |
| chr4:4,142,740–4,143,168 | 35.4 kb | Distal (>10kb) Multiome | 52 | |
| chr4:4,247,950–4,248,717 | 140.7 kb | Distal (>10kb) Multiome | 853 | |
| chr4:4,289,645–4,290,743 | 182.6 kb | Distal (>10kb) Multiome | 779 | |
| chr4:4,386,227–4,387,401 | 279.0 kb | Distal (>10kb) Multiome | 247 |
Genomic view of the ENSG00000290888 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.