This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for DPP9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DPP9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DPP9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:4,456,541–4,458,172 | 266.0 kb | Distal (>10kb) Multiome | 757 | |
| chr19:4,471,202–4,472,545 | 251.8 kb | Distal (>10kb) Multiome | 715 | |
| chr19:4,474,252–4,474,874 | 249.1 kb | Distal (>10kb) Multiome | 201 | |
| chr19:4,534,817–4,535,416 | 188.5 kb | Distal (>10kb) Multiome | 451 | |
| chr19:4,556,056–4,556,977 | 167.1 kb | Distal (>10kb) Multiome | 259 | |
| chr19:4,581,475–4,581,916 | 142.0 kb | Distal (>10kb) Multiome | 358 | |
| chr19:4,597,380–4,598,540 | 125.6 kb | Distal (>10kb) Multiome | 280 | |
| chr19:4,633,303–4,633,826 | 90.3 kb | Distal (>10kb) Multiome | 500 | |
| chr19:4,636,101–4,636,717 | 87.4 kb | Distal (>10kb) Multiome | 445 | |
| chr19:4,639,001–4,640,103 | 84.4 kb | Distal (>10kb) Multiome | 710 | |
| chr19:4,669,686–4,671,221 | 53.4 kb | Distal (>10kb) Multiome | 797 | |
| chr19:4,678,652–4,679,681 | 44.6 kb | Distal (>10kb) Multiome | 164 | |
| chr19:4,723,373–4,724,832 | 197 bp | At TSS Multiome | 1021 | |
| chr19:4,732,696–4,732,900 | 8.9 kb | Proximal (<10kb) | 231 | |
| chr19:4,791,166–4,792,360 | 67.7 kb | Distal (>10kb) Multiome HiCAR | 897 | |
| chr19:4,867,260–4,868,220 | 144.0 kb | Distal (>10kb) Multiome | 718 | |
| chr19:4,908,827–4,910,489 | 186.2 kb | Distal (>10kb) Multiome | 766 | |
| chr19:4,968,227–4,969,595 | 245.1 kb | Distal (>10kb) Multiome | 764 |
Genomic view of the DPP9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.