CRABP2

cellular retinoic acid binding protein 2 | CRABP-II

This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]

Member of: DE-7 DE-7.1 Developmental clusters: GC3

Biological processes 23 terms

cyclin binding (GO:0030332)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)endoplasmic reticulum (GO:0005783)epidermis development (GO:0008544)extracellular exosome (GO:0070062)fatty acid binding (GO:0005504)fatty acid transport (GO:0015908)lipid binding (GO:0008289)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)retinoic acid binding (GO:0001972)retinoic acid binding (GO:0001972)retinoid binding (GO:0005501)signal transduction (GO:0007165)

Expression (TPM)

TFs regulating CRABP2 0 TFs

Transcription factors with Perturb-seq knockdown data for CRABP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CRABP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CRABP2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CRABP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:156,420,712–156,422,291	284.1 kb	Distal (>10kb) Multiome	569
chr1:156,429,277–156,430,847	275.9 kb	Distal (>10kb) Multiome	231
chr1:156,432,112–156,432,986	273.2 kb	Distal (>10kb) Multiome	50
chr1:156,439,076–156,440,265	265.8 kb	Distal (>10kb) Multiome	264
chr1:156,456,348–156,457,982	249.1 kb	Distal (>10kb) Multiome	1033
chr1:156,499,927–156,501,599	204.8 kb	Distal (>10kb) Multiome	950
chr1:156,504,626–156,505,685	200.5 kb	Distal (>10kb) Multiome	911
chr1:156,572,298–156,572,749	133.2 kb	Distal (>10kb) Multiome	580
chr1:156,583,883–156,584,356	121.7 kb	Distal (>10kb) Multiome	183
chr1:156,591,252–156,592,285	114.0 kb	Distal (>10kb) Multiome	706
chr1:156,601,188–156,601,796	104.3 kb	Distal (>10kb) Multiome	759
chr1:156,624,123–156,624,848	81.3 kb	Distal (>10kb) Multiome	472
chr1:156,641,772–156,642,623	63.7 kb	Distal (>10kb) Multiome	211
chr1:156,657,279–156,657,727	48.3 kb	Distal (>10kb) Multiome	357
chr1:156,659,788–156,660,816	45.6 kb	Distal (>10kb) Multiome	901
chr1:156,673,575–156,674,145	31.9 kb	Distal (>10kb) Multiome	269
chr1:156,676,488–156,677,779	28.4 kb	Distal (>10kb) Multiome	449
chr1:156,689,084–156,690,144	16.2 kb	Distal (>10kb) Multiome	508
chr1:156,692,653–156,693,825	12.6 kb	Distal (>10kb) Multiome	493
chr1:156,703,427–156,704,626	1.9 kb	Proximal (<10kb) Multiome	182
chr1:156,704,839–156,707,238	355 bp	At TSS Multiome	728
chr1:156,708,331–156,708,813	2.6 kb	Proximal (<10kb) Multiome	108
chr1:156,728,152–156,729,282	22.9 kb	Distal (>10kb) Multiome	815
chr1:156,740,482–156,741,987	35.4 kb	Distal (>10kb) Multiome	1012
chr1:156,746,390–156,748,386	41.4 kb	Distal (>10kb) Multiome	750
chr1:156,751,012–156,752,594	46.0 kb	Distal (>10kb) Multiome	869
chr1:156,766,695–156,768,280	61.6 kb	Distal (>10kb) Multiome	967
chr1:156,813,606–156,814,470	108.2 kb	Distal (>10kb) Multiome	756
chr1:156,845,268–156,845,794	139.7 kb	Distal (>10kb) Multiome	73
chr1:156,848,614–156,849,138	143.1 kb	Distal (>10kb) Multiome	129
chr1:156,860,147–156,861,294	154.8 kb	Distal (>10kb) Multiome	484
chr1:156,862,753–156,863,585	157.4 kb	Distal (>10kb) Multiome	268
chr1:156,892,162–156,892,597	186.7 kb	Distal (>10kb) Multiome	439
chr1:156,893,409–156,893,975	188.0 kb	Distal (>10kb) Multiome	143
chr1:156,920,128–156,921,047	214.7 kb	Distal (>10kb) Multiome	508
chr1:156,927,257–156,928,255	222.0 kb	Distal (>10kb) Multiome	424
chr1:156,996,881–156,997,694	291.6 kb	Distal (>10kb) Multiome	167

Genome Browser

Genomic view of the CRABP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.