This gene belongs to the highly conserved copine family. It encodes a calcium-dependent, phospholipid-binding protein, which may be involved in membrane trafficking, mitogenesis and development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Transcription factors with Perturb-seq knockdown data for CPNE4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CPNE4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CPNE4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:131,526,553–131,527,375 | 508.0 kb | Distal (>10kb) Multiome HiCAR | 204 | |
| chr3:132,026,752–132,027,372 | 7.6 kb | Proximal (<10kb) | 13 | |
| chr3:132,027,486–132,027,623 | 7.4 kb | Proximal (<10kb) | 4 | |
| chr3:132,029,096–132,029,643 | 5.6 kb | Proximal (<10kb) Multiome | 269 | |
| chr3:132,034,105–132,035,411 | 71 bp | At TSS Multiome | 667 | |
| chr3:132,038,328–132,038,531 | 3.3 kb | Proximal (<10kb) | 82 | |
| chr3:132,283,581–132,286,246 | 250.7 kb | Distal (>10kb) Multiome | 334 | |
| chr3:132,295,035–132,295,625 | 9.6 kb | Proximal (<10kb) | 86 |
Genomic view of the CPNE4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.