The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for CCNI. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCNI upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCNI, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:76,801,591–76,802,890 | 274.0 kb | Distal (>10kb) Multiome | 200 | |
| chr4:76,867,647–76,869,012 | 207.6 kb | Distal (>10kb) Multiome | 115 | |
| chr4:76,896,697–76,898,709 | 177.8 kb | Distal (>10kb) Multiome | 498 | |
| chr4:76,948,267–76,951,238 | 127.0 kb | Distal (>10kb) Multiome | 968 | |
| chr4:77,012,534–77,013,096 | 63.2 kb | Distal (>10kb) Multiome | 56 | |
| chr4:77,074,968–77,076,780 | 257 bp | At TSS Multiome | 1071 | |
| chr4:77,084,016–77,084,805 | 8.4 kb | Proximal (<10kb) Multiome | 93 | |
| chr4:77,123,593–77,124,378 | 48.0 kb | Distal (>10kb) Multiome | 24 | |
| chr4:77,128,136–77,129,079 | 52.6 kb | Distal (>10kb) Multiome | 73 | |
| chr4:77,156,523–77,158,721 | 82.3 kb | Distal (>10kb) Multiome | 1039 | |
| chr4:77,175,021–77,175,714 | 99.5 kb | Distal (>10kb) Multiome | 259 | |
| chr4:77,193,476–77,193,939 | 117.6 kb | Distal (>10kb) Multiome | 188 |
Genomic view of the CCNI locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.