This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for BAMBI. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BAMBI upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BAMBI, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:28,459,483–28,460,059 | 217.7 kb | Distal (>10kb) Multiome | 45 | |
| chr10:28,518,834–28,519,331 | 158.4 kb | Distal (>10kb) Multiome | 47 | |
| chr10:28,532,042–28,534,170 | 144.7 kb | Distal (>10kb) Multiome | 975 | |
| chr10:28,668,533–28,669,159 | 8.6 kb | Proximal (<10kb) Multiome | 364 | |
| chr10:28,676,409–28,678,520 | 112 bp | At TSS Multiome | 900 | |
| chr10:28,678,653–28,679,374 | 1.1 kb | Proximal (<10kb) | 336 | |
| chr10:28,685,304–28,685,495 | 7.8 kb | Proximal (<10kb) | 138 | |
| chr10:28,686,833–28,687,591 | 9.9 kb | Proximal (<10kb) Multiome | 104 | |
| chr10:28,722,058–28,722,781 | 45.0 kb | Distal (>10kb) Multiome | 386 | |
| chr10:28,774,446–28,775,116 | 97.3 kb | Distal (>10kb) Multiome | 169 | |
| chr10:28,939,351–28,940,172 | 262.4 kb | Distal (>10kb) Multiome HiCAR | 804 | |
| chr10:29,273,431–29,273,931 | 596.2 kb | Distal (>10kb) Multiome HiCAR | 102 |
Genomic view of the BAMBI locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.