This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for APOBEC3F. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = APOBEC3F upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of APOBEC3F, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:38,755,428–38,756,383 | 284.8 kb | Distal (>10kb) Multiome | 770 | |
| chr22:38,793,674–38,794,378 | 246.7 kb | Distal (>10kb) Multiome | 484 | |
| chr22:38,843,207–38,844,443 | 197.0 kb | Distal (>10kb) Multiome | 585 | |
| chr22:38,866,394–38,866,832 | 174.3 kb | Distal (>10kb) Multiome | 76 | |
| chr22:38,871,208–38,873,237 | 168.5 kb | Distal (>10kb) Multiome | 758 | |
| chr22:39,014,028–39,014,530 | 26.6 kb | Distal (>10kb) Multiome | 367 | |
| chr22:39,020,588–39,021,215 | 19.9 kb | Distal (>10kb) Multiome | 149 | |
| chr22:39,040,158–39,041,304 | 47 bp | At TSS Multiome | 237 | |
| chr22:39,077,158–39,077,634 | 36.4 kb | Distal (>10kb) Multiome | 66 | |
| chr22:39,087,857–39,088,400 | 47.2 kb | Distal (>10kb) Multiome | 32 | |
| chr22:39,144,772–39,146,359 | 104.8 kb | Distal (>10kb) Multiome | 668 | |
| chr22:39,152,016–39,153,700 | 111.9 kb | Distal (>10kb) Multiome | 607 | |
| chr22:39,170,852–39,171,359 | 130.2 kb | Distal (>10kb) Multiome | 425 | |
| chr22:39,174,292–39,175,258 | 134.0 kb | Distal (>10kb) Multiome | 688 | |
| chr22:39,179,438–39,180,229 | 138.8 kb | Distal (>10kb) Multiome | 84 | |
| chr22:39,229,884–39,230,835 | 189.3 kb | Distal (>10kb) Multiome | 417 | |
| chr22:39,242,211–39,244,345 | 202.0 kb | Distal (>10kb) Multiome | 605 | |
| chr22:39,310,537–39,311,897 | 270.3 kb | Distal (>10kb) Multiome | 655 | |
| chr22:39,319,163–39,320,470 | 278.9 kb | Distal (>10kb) Multiome | 968 |
Genomic view of the APOBEC3F locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.