Enables beta-catenin binding activity. Involved in negative regulation of cell-matrix adhesion; negative regulation of wound healing; and regulation of polarized epithelial cell differentiation. Located in several cellular components, including adherens junction; basolateral plasma membrane; and cell-cell contact zone. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for AJAP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AJAP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AJAP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:3,899,608–3,901,755 | 753.2 kb | Distal (>10kb) Multiome HiCAR | 1026 | |
| chr1:3,910,694–3,911,367 | 743.6 kb | Distal (>10kb) Multiome HiCAR | 321 | |
| chr1:4,652,598–4,653,212 | 1.4 kb | Proximal (<10kb) | 267 | |
| chr1:4,653,349–4,653,557 | 1.1 kb | Proximal (<10kb) | 59 | |
| chr1:4,653,855–4,656,775 | 1.9 kb | Proximal (<10kb) Multiome | 236 | |
| chr1:4,659,022–4,659,187 | 4.4 kb | Proximal (<10kb) | 36 | |
| chr1:4,660,986–4,661,543 | 6.6 kb | Proximal (<10kb) Multiome | 123 | |
| chr1:4,710,737–4,711,736 | 56.5 kb | Distal (>10kb) Multiome | 293 | |
| chr1:4,714,909–4,715,283 | 3.8 kb | Proximal (<10kb) | 17 | |
| chr1:4,803,203–4,804,335 | 149.0 kb | Distal (>10kb) Multiome | 130 | |
| chr1:5,225,357–5,227,093 | 571.8 kb | Distal (>10kb) Multiome HiCAR | 289 | |
| chr1:5,980,417–5,980,986 | 1326.0 kb | Distal (>10kb) Multiome HiCAR | 282 |
Genomic view of the AJAP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.