The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAPK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAPK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAPK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:29,862,597–29,863,901 | 259.7 kb | Distal (>10kb) Multiome | 953 | |
| chr16:29,876,281–29,878,282 | 245.5 kb | Distal (>10kb) Multiome | 319 | |
| chr16:29,899,174–29,900,833 | 223.7 kb | Distal (>10kb) Multiome | 1019 | |
| chr16:29,925,692–29,926,784 | 196.9 kb | Distal (>10kb) Multiome | 912 | |
| chr16:29,961,477–29,962,530 | 161.2 kb | Distal (>10kb) Multiome | 848 | |
| chr16:29,973,238–29,974,906 | 149.4 kb | Distal (>10kb) Multiome | 935 | |
| chr16:29,994,888–29,996,728 | 127.0 kb | Distal (>10kb) Multiome | 1080 | |
| chr16:30,021,215–30,021,860 | 101.6 kb | Distal (>10kb) Multiome | 764 | |
| chr16:30,052,803–30,053,364 | 70.0 kb | Distal (>10kb) Multiome | 989 | |
| chr16:30,063,722–30,066,296 | 59.1 kb | Distal (>10kb) Multiome | 1209 | |
| chr16:30,075,490–30,076,439 | 47.2 kb | Distal (>10kb) Multiome | 828 | |
| chr16:30,090,881–30,092,910 | 30.3 kb | Distal (>10kb) Multiome | 1101 | |
| chr16:30,095,557–30,096,839 | 26.8 kb | Distal (>10kb) Multiome | 824 | |
| chr16:30,122,728–30,123,578 | 96 bp | At TSS Multiome | 718 | |
| chr16:30,182,759–30,183,865 | 60.3 kb | Distal (>10kb) Multiome | 547 | |
| chr16:30,334,526–30,335,777 | 212.2 kb | Distal (>10kb) Multiome | 486 | |
| chr16:30,354,854–30,355,978 | 232.3 kb | Distal (>10kb) Multiome | 1070 | |
| chr16:30,369,220–30,371,611 | 247.6 kb | Distal (>10kb) Multiome | 818 | |
| chr16:30,377,495–30,379,532 | 255.2 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,394,422–30,396,098 | 272.1 kb | Distal (>10kb) Multiome | 941 | |
| chr16:30,400,026–30,401,048 | 277.4 kb | Distal (>10kb) Multiome | 839 | |
| chr16:30,406,974–30,408,429 | 284.3 kb | Distal (>10kb) Multiome | 908 | |
| chr16:30,417,414–30,418,576 | 294.9 kb | Distal (>10kb) Multiome | 543 |
Genomic view of the MAPK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.