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DE-6.15

Submodule 12 genes

DNA repair and recombination machinery

This module contains 12 genes including MRE11, DDX11, and RAD54B, with enrichment in DNA repair and homologous recombination processes. No transcription factor knockdown data are available for this module. No repressing transcription factors have been identified.

Key terms: sister chromatid cohesion double-strand break repair positive regulation of double-strand break repair positive regulation of chromosome organization Notable genes: MRE11 DDX11 RAD54B CNTLN MOB3B ARGLU1 FIRRM IPO9

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (12)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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High z
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