Enables histone binding activity; histone chaperone activity; and nuclear import signal receptor activity. Involved in proteasome localization and protein import into nucleus. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for IPO9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IPO9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IPO9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:201,538,592–201,540,560 | 288.9 kb | Distal (>10kb) Multiome HiCAR | 592 | |
| chr1:201,559,535–201,560,001 | 269.3 kb | Distal (>10kb) Multiome HiCAR | 463 | |
| chr1:201,614,255–201,614,715 | 214.7 kb | Distal (>10kb) Multiome | 227 | |
| chr1:201,648,049–201,650,866 | 178.8 kb | Distal (>10kb) Multiome | 533 | |
| chr1:201,678,604–201,679,421 | 150.2 kb | Distal (>10kb) Multiome | 158 | |
| chr1:201,709,409–201,709,946 | 119.5 kb | Distal (>10kb) Multiome | 258 | |
| chr1:201,739,028–201,740,430 | 89.4 kb | Distal (>10kb) Multiome | 287 | |
| chr1:201,828,821–201,829,863 | 71 bp | At TSS Multiome | 821 | |
| chr1:201,888,189–201,889,202 | 59.7 kb | Distal (>10kb) Multiome | 335 | |
| chr1:201,895,782–201,896,239 | 66.9 kb | Distal (>10kb) Multiome | 606 | |
| chr1:201,941,439–201,942,399 | 112.8 kb | Distal (>10kb) Multiome | 508 | |
| chr1:201,946,301–201,946,923 | 117.4 kb | Distal (>10kb) Multiome | 290 | |
| chr1:201,955,139–201,955,899 | 126.3 kb | Distal (>10kb) Multiome | 881 | |
| chr1:201,982,248–201,983,657 | 154.2 kb | Distal (>10kb) Multiome | 875 | |
| chr1:202,007,961–202,008,615 | 179.1 kb | Distal (>10kb) Multiome | 368 | |
| chr1:202,009,428–202,011,367 | 181.4 kb | Distal (>10kb) Multiome | 761 | |
| chr1:202,075,813–202,076,531 | 247.0 kb | Distal (>10kb) Multiome | 418 | |
| chr1:202,101,336–202,102,103 | 272.7 kb | Distal (>10kb) Multiome | 173 | |
| chr1:202,105,597–202,106,270 | 276.8 kb | Distal (>10kb) Multiome | 376 |
Genomic view of the IPO9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.