This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MRE11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MRE11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MRE11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:94,351,024–94,351,644 | 142.5 kb | Distal (>10kb) Multiome | 45 | |
| chr11:94,400,876–94,402,024 | 92.4 kb | Distal (>10kb) Multiome | 221 | |
| chr11:94,493,226–94,494,559 | 80 bp | At TSS Multiome | 772 | |
| chr11:94,512,016–94,512,839 | 18.7 kb | Distal (>10kb) Multiome | 343 | |
| chr11:94,543,659–94,545,776 | 50.4 kb | Distal (>10kb) Multiome | 824 | |
| chr11:94,643,177–94,643,647 | 149.6 kb | Distal (>10kb) Multiome | 75 | |
| chr11:94,649,720–94,650,679 | 156.4 kb | Distal (>10kb) Multiome | 129 | |
| chr11:94,734,354–94,735,444 | 240.9 kb | Distal (>10kb) Multiome | 313 | |
| chr11:94,740,333–94,741,667 | 246.9 kb | Distal (>10kb) Multiome | 433 | |
| chr11:94,766,900–94,769,104 | 273.3 kb | Distal (>10kb) Multiome | 701 |
Genomic view of the MRE11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.