Enables pre-mRNA binding activity and transcription coactivator activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in cytosol; mitochondrion; and nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ARGLU1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARGLU1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARGLU1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:106,343,410–106,344,359 | 224.2 kb | Distal (>10kb) Multiome | 105 | |
| chr13:106,528,857–106,529,650 | 38.9 kb | Distal (>10kb) Multiome | 187 | |
| chr13:106,532,933–106,536,887 | 32.4 kb | Distal (>10kb) Multiome | 829 | |
| chr13:106,567,154–106,568,773 | 30 bp | At TSS Multiome | 777 | |
| chr13:106,569,780–106,569,994 | 2.2 kb | Proximal (<10kb) | 19 | |
| chr13:106,570,132–106,570,917 | 2.5 kb | Proximal (<10kb) Multiome | 174 | |
| chr13:106,574,348–106,574,869 | 6.7 kb | Proximal (<10kb) | 5 | |
| chr13:106,617,405–106,618,038 | 49.6 kb | Distal (>10kb) Multiome | 130 | |
| chr13:106,680,668–106,681,707 | 113.1 kb | Distal (>10kb) Multiome | 242 | |
| chr13:106,795,669–106,797,367 | 228.6 kb | Distal (>10kb) Multiome | 499 | |
| chr13:106,858,489–106,859,979 | 291.0 kb | Distal (>10kb) Multiome | 242 | |
| chr13:106,917,249–106,918,514 | 349.8 kb | Distal (>10kb) Multiome HiCAR | 480 |
Genomic view of the ARGLU1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.