The protein encoded by this gene shares similarity with the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. This gene is located on the opposite strand as the interferon kappa precursor (IFNK) gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MOB3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MOB3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MOB3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:27,353,413–27,354,230 | 176.0 kb | Distal (>10kb) Multiome HiCAR | 252 | |
| chr9:27,369,370–27,370,284 | 160.0 kb | Distal (>10kb) Multiome HiCAR | 166 | |
| chr9:27,527,691–27,530,287 | 1.4 kb | Proximal (<10kb) Multiome | 646 | |
| chr9:27,535,686–27,536,267 | 5.9 kb | Proximal (<10kb) | 94 | |
| chr9:27,572,547–27,574,260 | 43.9 kb | Distal (>10kb) Multiome | 778 | |
| chr9:27,749,616–27,750,339 | 220.2 kb | Distal (>10kb) Multiome | 209 | |
| chr9:27,771,599–27,772,601 | 242.2 kb | Distal (>10kb) Multiome | 306 |
Genomic view of the MOB3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.