Enables protein domain specific binding activity; protein kinase binding activity; and protein-macromolecule adaptor activity. Involved in centriole-centriole cohesion and protein localization to organelle. Located in cytosol; microtubule organizing center; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CNTLN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CNTLN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CNTLN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:16,869,935–16,872,271 | 264.3 kb | Distal (>10kb) Multiome | 468 | |
| chr9:17,080,891–17,082,079 | 53.6 kb | Distal (>10kb) Multiome | 179 | |
| chr9:17,134,290–17,135,974 | 75 bp | At TSS Multiome | 810 | |
| chr9:17,394,734–17,395,506 | 260.1 kb | Distal (>10kb) Multiome | 91 | |
| chr9:17,397,274–17,397,749 | 262.5 kb | Distal (>10kb) Multiome | 86 | |
| chr9:19,126,915–19,128,564 | 1992.6 kb | Distal (>10kb) Multiome HiCAR | 808 |
Genomic view of the CNTLN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.