This module contains 18 genes including SIGMAR1, SV2A, SLC5A6, HERC5, and MYCBP, with top enriched terms related to solute transport and autophagy-related processes. Knockdown of SOX17 activates this module, while knockdown of NANOG and OCT4 repress it. These regulatory patterns suggest the module is suppressed in pluripotent stem cells and upregulated during endoderm commitment.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.