The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for MYCBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYCBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYCBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:38,012,220–38,013,284 | 860.7 kb | Distal (>10kb) Multiome HiCAR | 1074 | |
| chr1:38,803,885–38,804,528 | 69.1 kb | Distal (>10kb) Multiome | 257 | |
| chr1:38,817,720–38,818,696 | 55.1 kb | Distal (>10kb) Multiome | 375 | |
| chr1:38,859,087–38,860,584 | 13.5 kb | Distal (>10kb) Multiome | 848 | |
| chr1:38,872,771–38,873,884 | 77 bp | At TSS Multiome | 778 | |
| chr1:38,990,541–38,992,051 | 117.8 kb | Distal (>10kb) Multiome | 902 | |
| chr1:39,025,981–39,026,877 | 153.0 kb | Distal (>10kb) Multiome | 808 | |
| chr1:39,080,764–39,081,936 | 207.9 kb | Distal (>10kb) Multiome | 352 | |
| chr1:39,104,780–39,106,278 | 232.4 kb | Distal (>10kb) Multiome | 621 | |
| chr1:39,132,955–39,133,390 | 259.9 kb | Distal (>10kb) Multiome | 384 |
Genomic view of the MYCBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.