The protein encoded by this gene is one of three related synaptic vesicle proteins. The encoded protein may interact with synaptotagmin to enhance low frequency neurotransmission in quiescent neurons. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for SV2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SV2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SV2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:149,636,175–149,637,106 | 281.3 kb | Distal (>10kb) Multiome | 687 | |
| chr1:149,812,136–149,812,633 | 105.5 kb | Distal (>10kb) Multiome | 190 | |
| chr1:149,885,029–149,889,131 | 29.6 kb | Distal (>10kb) Multiome | 1126 | |
| chr1:149,899,425–149,900,227 | 18.2 kb | Distal (>10kb) Multiome | 650 | |
| chr1:149,917,583–149,918,019 | at TSS | At TSS | 232 | |
| chr1:149,927,507–149,928,019 | 10.1 kb | Distal (>10kb) Multiome | 744 | |
| chr1:150,010,143–150,011,088 | 92.9 kb | Distal (>10kb) Multiome | 961 | |
| chr1:150,066,903–150,067,886 | 149.8 kb | Distal (>10kb) Multiome | 986 | |
| chr1:150,149,493–150,150,439 | 232.2 kb | Distal (>10kb) Multiome | 448 | |
| chr1:150,162,838–150,163,636 | 245.4 kb | Distal (>10kb) Multiome | 550 | |
| chr1:150,213,532–150,214,095 | 295.9 kb | Distal (>10kb) Multiome | 441 |
Genomic view of the SV2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.