This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for SIGMAR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIGMAR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIGMAR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:34,363,597–34,364,212 | 273.9 kb | Distal (>10kb) Multiome | 104 | |
| chr9:34,374,953–34,375,681 | 262.6 kb | Distal (>10kb) Multiome | 432 | |
| chr9:34,376,008–34,377,655 | 260.8 kb | Distal (>10kb) Multiome | 779 | |
| chr9:34,379,248–34,381,674 | 256.9 kb | Distal (>10kb) Multiome | 763 | |
| chr9:34,456,881–34,459,235 | 179.2 kb | Distal (>10kb) Multiome | 704 | |
| chr9:34,522,211–34,523,972 | 114.6 kb | Distal (>10kb) Multiome | 473 | |
| chr9:34,577,374–34,578,752 | 59.8 kb | Distal (>10kb) Multiome | 204 | |
| chr9:34,589,298–34,591,068 | 48.0 kb | Distal (>10kb) Multiome | 258 | |
| chr9:34,591,283–34,592,013 | 46.0 kb | Distal (>10kb) Multiome | 368 | |
| chr9:34,611,663–34,612,738 | 25.6 kb | Distal (>10kb) Multiome HiCAR | 680 | |
| chr9:34,612,834–34,613,263 | 24.7 kb | Distal (>10kb) Multiome | 343 | |
| chr9:34,620,108–34,620,704 | 17.3 kb | Distal (>10kb) Multiome HiCAR | 467 | |
| chr9:34,628,770–34,629,308 | 8.8 kb | Proximal (<10kb) Multiome HiCAR | 216 | |
| chr9:34,633,805–34,634,175 | 3.6 kb | Proximal (<10kb) | 199 | |
| chr9:34,637,123–34,638,475 | 59 bp | At TSS Multiome | 872 | |
| chr9:34,646,247–34,647,338 | 8.9 kb | Proximal (<10kb) Multiome | 857 | |
| chr9:34,651,771–34,652,431 | 14.3 kb | Distal (>10kb) Multiome | 669 | |
| chr9:34,664,346–34,666,446 | 27.8 kb | Distal (>10kb) Multiome | 707 | |
| chr9:34,674,895–34,675,574 | 37.4 kb | Distal (>10kb) Multiome | 372 | |
| chr9:34,701,127–34,701,863 | 63.6 kb | Distal (>10kb) Multiome | 390 |
Genomic view of the SIGMAR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.