Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for GYPC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GYPC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GYPC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:126,655,117–126,655,457 | 725 bp | At TSS | 97 | |
| chr2:126,655,553–126,656,883 | 146 bp | At TSS Multiome | 442 | |
| chr2:126,656,984–126,658,527 | 1.7 kb | Proximal (<10kb) Multiome | 685 | |
| chr2:126,776,225–126,778,048 | 120.6 kb | Distal (>10kb) Multiome | 565 | |
| chr2:126,778,457–126,779,633 | 122.8 kb | Distal (>10kb) Multiome | 207 | |
| chr2:126,808,877–126,809,850 | 153.0 kb | Distal (>10kb) Multiome | 179 | |
| chr2:126,885,475–126,887,048 | 230.3 kb | Distal (>10kb) Multiome | 524 | |
| chr2:126,908,609–126,909,652 | 253.0 kb | Distal (>10kb) Multiome | 59 | |
| chr2:126,942,302–126,943,261 | 286.5 kb | Distal (>10kb) Multiome | 184 |
Genomic view of the GYPC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.