The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for DIS3L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DIS3L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DIS3L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:66,252,061–66,253,967 | 41.3 kb | Distal (>10kb) Multiome | 412 | |
| chr15:66,293,215–66,294,349 | 161 bp | At TSS Multiome | 772 | |
| chr15:66,356,371–66,357,196 | 62.9 kb | Distal (>10kb) Multiome | 889 | |
| chr15:66,386,387–66,387,653 | 93.0 kb | Distal (>10kb) Multiome | 899 | |
| chr15:66,472,216–66,473,164 | 178.7 kb | Distal (>10kb) Multiome | 208 | |
| chr15:66,497,104–66,498,247 | 204.0 kb | Distal (>10kb) Multiome | 1044 | |
| chr15:66,504,543–66,505,655 | 211.3 kb | Distal (>10kb) Multiome | 940 | |
| chr15:66,567,056–66,567,492 | 273.4 kb | Distal (>10kb) Multiome | 294 | |
| chr15:66,592,463–66,593,143 | 299.0 kb | Distal (>10kb) Multiome | 154 |
Genomic view of the DIS3L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.